Home Metabolism P450 (e.g. CYP17) inhibitor TMS

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TMS P450 (e.g. CYP17) inhibitor

Cat.No.E0531

TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive human cytochrome P450s B1 (CYP1B1) inhibitor with an IC50 of 6 nM.
TMS P450 (e.g. CYP17) inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 300.35

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: E053101 DMSO]60 mg/mL]false]Ethanol]8 mg/mL]false]Water]Insoluble]false Purity: 99.86%
99.86

Chemical Information, Storage & Stability

Molecular Weight 300.35 Formula

C18H20O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 24144-92-1 -- Storage of Stock Solutions

Synonyms (E)-2,3',4,5'-tetramethoxystilbene Smiles COC1=CC=C(\C=C\C2=CC(=CC(=C2)OC)OC)C(=C1)OC

Solubility

In vitro
Batch:

DMSO : 60 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
CYP1B1 [1]
(in biological assay)
6 nM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06231563 Not yet recruiting
Parkinson?s Disease
VA Office of Research and Development
 July 1 2024 Phase 2
NCT06266390 Not yet recruiting
Depression|Major Depressive Disorder|Persistent Depressive Disorder
University of Pennsylvania|National Institutes of Health (NIH)
 June 30 2024 Phase 1
NCT06381388 Not yet recruiting
Stroke
Jord Vink|UMC Utrecht
 June 1 2024 Not Applicable

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